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Veltride (Dutasteride)
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Dutasteride

Veltride is a synthetic 4-azasteroid compound. Veltride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Seven metabolites (norscopine, scopine, tropic acid, aponorscopolamine, aposcopolamine, norscopolamine, and hydroxyscopolamine) and the parent drug are detected in rat plasma. In cultured human osteosarcoma cells, RA enhances the expression of bone morphogenetic protein-7 (BMP7), a trophic factor that reduces ischemia- or neurotoxin-mediated neurodegeneration in vivo. In contrast, the lowest active dose level of NP (0.073 mg/kg/day) in the Noble rat mammary gland study was about 600 times lower than its minimum detection level in rat uterotrophic and multigeneration studies. We evaluated the procedure in a consecutive series of 100 patients who underwent laparoscopic gastric bypass.

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Temporal allozyme divergence in infrapopulations of the hemiurid fluke Lecithochirium fusiforme. Thus, similar strengths of selection can lead to similar levels of disequilibrium over a fixed time and a range of small recombination rates. Valuable structural information from glycosylation effects is taken into account for the development of a V3 loop rational structure-based vaccine strategy using N295 and N302 as potential conformational epitope. Virally encoded E6 protein utilizes the cellular ubiquitin-protein ligase termed E6-associated protein (E6-AP) to target p53 protein for proteolytic degradation.

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The efficacy of induction therapy is associated with WBC at diagnosis, karyotype and induction regimen. Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy. In single model presentation tests, a model containing a natural head and neck with an artificial body was as effective in eliciting copulatory behavior as a whole body model, but a model containing a natural body with an artificial head and neck was largely ineffective.

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Quantal nature of transmission at the synapse between hair cells and eighth nerve fibers. A picture emerges that at least part of these effects are due to a complex modulation of GABAergic system in developing and adult hippocampus.

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Atrial flutter (AFL) has been shown to be more frequently inducible in patients with AVNRT. Genomic duplication, fractionation and the origin of regulatory novelty. A brief survey of these methods and the results obtained is given. EC-specific Srf deletion led to aneurysms and hemorrhages from 11.5 days of mouse development (E11.5) and lethality at E14.5. In this article, we review the long journey from the discovery of the glucosuric agent phlorizin in the bark of the apple tree through the animal and human studies that led to the development of the current generation of SGLT2 inhibitors.

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This case illustrates the importance of echocardiography in making this rare diagnosis. In addition, the endoscopic placement of the femoral screw had an associated divergence of the screw relative to the bone plug in nine of 25 patients compared with zero of 25 in the open group. The present review describes the 35 cases of RS published in the indexed literature (Medline)--the first corresponding to 1985 and the last to the year 2007.

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Asymptomatic patients can be evaluated as non-urgent outpatients if there is concern for exposures to high doses (e.g., more than contained in a thermometer) or for chronic duration (Grade D). To study whether physical activity has a protective effect on the development and progression of myopia in medical students. Results were then independently validated using an observational data set.

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In mys mutants that fail to establish contact between the extraembryonic membranes, the amnioserosa undergoes premature disintegration and death. Self-assembled monolayers of an oligo(ethylene oxide) disulfide and its corresponding thiol assembled from water: characterization and protein resistance. Utility of fine needle aspiration cytology in detecting metastatic deposits in an uncommon case of malignant transformation in a giant cell tumour of bone.

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Alerting can induce seizures in encephalopathic/comatose patients. We collected blood from MS patients and controls, amplified and sequenced the latent membrane protein-1 (LMP-1) gene, and compared the groups. The genetic association of DBP with COPD may be mediated by effects on macrophage activation, since DBP relates to FEV(1), and affects macrophage activation. Recombinant human platelet-activating factor acetylhydrolase reduces the frequency of diabetes in the diabetes-prone BB rat.

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Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide. In contrast, animals that received linearized DNA by a single cut in the bacterial backbone had similar expression profiles to that of intact plasmid groups. In a pathogen, cell wall proteins are important virulence factors. Development of the neuromuscular junction (NMJ) is initiated by the formation of postsynaptic specializations in the central zones of muscles, followed by the arrival of motor nerve terminals opposite the postsynaptic regions. In adults, testing can enhance subsequent learning by reducing interference from the tested information.

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A methodology is introduced to assign energy-based scores to two-dimensional (2D) structural features based on three-dimensional (3D) ligand-target interaction information and utilize interaction-annotated features in virtual screening. Compliant patients who are seen in scheduled follow-up, and who display signs of infection or wound issues at the site of the umbilicus, usually have these factors addressed before inclusion cysts manifest.

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Placing a drain during transplantation decreased the incidence of fluid collection, lymphocele treatment and DVT. This study explores the implications for cancer induction of treatment details such as fractionation, planning target volume (PTV) definition, and interpatient variations, which are relevant for the radiation treatment of prostate carcinomas. This presentation looks at how scotopic light sources and dark-adapted radiologists may identify more real diseases. Non-destructive evaluation of depth of surface cracks using ultrasonic frequency analysis.

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Comprehensive prediction of chromosome dimer resolution sites in bacterial genomes. The complete form may cause symptoms by compressing the esophagus or the trachea and need a surgical intervention.

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Although inception cohort studies of patients with low back pain have indicated the prognostic relevance of psychosocial work-related factors for return to work, these factors and the interaction of these factors with restrictions in functional capacity have been less extensively considered during the rehabilitation process so far. Fibroblast growth factor 23 (FGF23) is a humoral factor that is produced by osteocytes and reduces serum phosphate and 1,25-dihydroxyvitamin D levels by acting on kidney through some FGF receptor and Klotho. Lower urinary tract symptoms (LUTS) have been associated with comorbid conditions such as anxiety and depression.

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These results clearly ascertained the antiglycoxidative properties of astaxanthin derived from C. Acinar cell apoptosis was atypical in that cell fragmentation was limited and phagocytosis delayed, resulting in extensive secondary necrosis. Protein tyrosine phosphatase (PTP) is a family of enzymes important for regulating cellular phosphorylation state. More effective taxanes should be investigated further in urothelial carcinoma in combination with gemcitabine/platinum.

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In general, calcein release decreased with decreasing droplet size, as hypothesized based on Laplace pressure. The maximum cross-sectional mass of the fibrils increases exponentially with increasing fibril length. The results suggest that alterations of H2S signaling in the brain may be associated with the development of hypertension. Association between Oral Mucosal Lesions and Hygiene Habits in a Population of Removable Prosthesis Wearers. Pleurodesis is a relatively safe procedure, although previous studies have described malignant invasion of scar tissue.

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Tumor with features of renal cell carcinoma and of transitional cell carcinoma. This review focuses on the potential safety and efficacy of herbs which are either used often or even on a daily basis by patients with hematological malignancies or indicated in the herbal pharmacopeias utilized by various traditional systems of medicine, in order to improve the well-being of patients with these cancers. Inflammatory lung injury is an inevitable consequence of cardiac surgery with cardiopulmonary bypass.

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(2) Periodic injection of cAMP pulses into aggregation streams blocked the pulses coming from the center and led to the rapid accumulation of cells downstream of the pipet around the pipet. Community-based studies have documented gender differences in mental health problems and service utilization. Seven Candida strains, one Cryptococcus unigutulatus and two Trichosporon asahii strains were isolated.

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TAP forms a heterodimer where each subunit consists of a hydrophilic nucleotide binding domain and a hydrophobic transmembrane domain. MCF-7 and LNCaP cells were treated with L-methionine (5 mg/ml) for 72 h. Concomitant with MYCN down-regulation, the level of MRP expression was decreased in the NBAS-4 and NBAS-5 antisense transfectants.

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The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism. A 10-year-old Hanoverian mare was evaluated for a right buccal swelling that recurred 3 months following surgical resection.

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For symmetric lattice sites, and a magnetic field parallel to the lattice axis, we compare the measured dipolar relaxation rate with a Fermi golden rule calculation. In Section III.C we explain how we specifically label our microfabricated structures, and in Section III.D we present how these functionalized microfabricated structures are incorporated into assays, with a discussion of the details of the assays themselves. To determine if feline lacrimal glands, glands of the third eyelid, corneas, and corneal sequestra contain porphyrins, which could be responsible for the brown/amber discoloration of corneal sequestra and tears in affected cats. Over the past 40 years, growing interest in the field of sugar recognition has led to the development of several promising artificial receptors, which could soon find widespread use in medical diagnostics and cell imaging.

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Pregnant rats with adriamycin nephropathy (ADRP rats) develop hypertension and have an increased vascular reactivity to noradrenaline in the isolated mesenteric bed in vitro. A successful treatment with down-staging chemotherapy for sigmoid colon cancer with unresectable multiple liver and lung metastases One hundred twenty-eight patients with pemphigus vulgaris, treated with prednisolone 2 mg/kg/day plus azathioprine 2 to 2.5 mg/kg/day, were enrolled.

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Furthermore, heterochronic combinations of retarded and accelerated phenotypes caused by impaired BR-C function suggest that besides specifying the pupal fate, BR-C operates as a temporal coordinator of hormonally regulated morphogenetic events across epidermal tissues. A novel antifolate resistance gene on the amplified H circle of Leishmania. Meanwhile, cellular Cytochrome C increased and Bcl-2 decreased obviously in cells expressing PrP-PG0, indicating triggering a mitochondrial-related apoptosis.

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Influence of photoperiod on immune cell functions in the male Siberian hamster. This study was undertaken to define the role of costimulation in osteoclast differentiation during inflammatory arthritis. A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files. This study quantifies the neurological structures of the ACL from proximal to distal in the zones A, B and C. Ceftriaxone has also been shown to modulate the proteasome system, thus decreasing NF-kappaB activation and GFAP promoter transcriptional regulation, which further accounts for the down-modulation of GFAP protein levels.

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This study uses a unique dataset linking the birth records of two generations of children born in California and Florida (1970-2009) to analyze the mechanisms behind the generational decline observed in birth outcomes of children of Mexican origin. Peripheral vascular disease (PVD) is associated with an increased risk of cardiovascular disease.

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Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia. One influential explanation for the costs incurred when switching between tasks is that they reflect interference arising from completing the previous task-known as task-set inertia.

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Facial lipoatrophy can stigmatize and can reduce quality of life, self esteem, and antiretroviral adherence. Phosphorus species and fractionation--why sewage derived phosphorus is a problem. The Akt-FoxO1 signaling pathway plays an essential role during liver regeneration.

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Taken together, these findings may be pertinent to further clinical exploitation of plasma sVEGFR-2 levels as a surrogate biomarker of VEGF-dependent tumor growth as well as an activity indicator of antiangiogenic drugs that target the VEGFR system. A library of chiral imidazoline-aminophenol ligands: discovery of an efficient reaction sphere. Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse escitalopram interaction with dicyclomine kidney. Influence of anabolic steroids on thyroid function in normal and dyscrinic children However, the mechanisms through which glucocorticoids inhibit growth of new blood vessels have not been established.