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Valcivir (Valacyclovir)
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Valacyclovir

Valcivir is the hydrochloride salt of the L-valyl ester of the antiviral drug acyclovir. Orally administered, Valcivir is rapidly converted to acyclovir which inhibits viral DNA replication after further conversion to the nucleotide analog acyclovir triphosphate by viral thymidine kinase, cellular guanyl cyclase, and a number of other cellular enzymes. Acyclovir triphosphate competitively inhibits viral DNA polymerase; incorporates into and terminates the growing viral DNA chain; and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against herpes simplex virus (HSV) compared with varicellla-zoster virus (VZV) is due to its more efficient phosphorylation by HSV thymidine kinase.

Other names for this medication:
Valacyclovir, Valtrex, Bagovir, Herclov, Rapivir, Talavir, Vadiral, Valaciclovir, Valavir, Valcivir, Valvir, Valvirex, Viranet, Zelitrex,

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Following mucosal exposure to supernatants from control subjects and IBS-D patients, electromyographic response to colorectal balloon distension was recorded in wild-type and PAR-2(-/-) mice, and CPP was evaluated on colonic strips in Ussing chambers. The role of IL-5 and eosinophils in allograft rejection was studied in human liver allograft recipients. When introduced into human CRC cells by homologous recombination, the Thr300Ala variant did not affect bulk autophagy, but increased basal production of type I IFN. Inasmuch as Apteronotus does regenerate its spinal cord naturally after injury, whereas mammals do not, this culture system will be useful to study factors that control (permit) regeneration of spinal neurons in this adult vertebrate.

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Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. Routine oral examinations in primary care: which predictors determine what is done?

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Craniofacial morphology of orthodontically untreated patients living in Saxony, Germany. To shed light on the complex phenotype of embryonic arrest, we undertook a systematic approach, aiming at the definition of the altered proteomic profile of feh-1 null worms. Validity of the Short Nutritional Assessment Questionnaire for Japanese Patients with Cancer Undergoing Outpatient Chemotherapy. By comparing the age-hardening curve with the changes in full-width at half-maximum of the XRD peaks at each ageing time, it was revealed that the coherency strains were formed in the Ag-rich matrix, which contributed to the hardness increase during ageing.

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