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Spiroctan (Spironolactone)

Spiroctan is a synthetic 17-Spiroctan corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spiroctan competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for active clinical trials using this agent.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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We surveyed all internal medicine residents at Rhode Island Hospital regarding whether they found PMAs useful, what percentage of their patients taking chronic opioids had a signed PMA, and their attitudes toward and experiences with managing CNCP. Prostate cancer had a development predominantly at peripheral gland and stay for a long time asymptomatic without clinical symptoms. The stimulation of flux through glucokinase by low concentrations of fructose decreased the proportion of glucose phosphorylated, which was cycled between glucose and glucose 6-phosphate, and increased the proportion that was glycolysed. In contrast with the previous automatic analyses of EEG which were focussed on certain aspects of EEG such as the dominant rhythm, the present system is unique in its capability of providing an integrative interpretation of the spontaneous awake EEG by taking into account all its features except for paroxysmal abnormalities.

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The aim of this study was to evaluate whether the magnitude of their negative effects is related to recipient model for end-stage liver disease (MELD) score. The analgesic interaction between intrathecally administered bupivacaine and clonidine was examined during acute thermal and inflammatory-induced pain in rats. Using ultrastructural studies, it was possible to demonstrate the survival of H.

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In particular it seems that relatives reductions in facial medium third, in nose dimensions and in distance between eyes have occurred as well as relative enlargement of eyes and mouth width. A significant positive association was found between the behaviors of reflection and legitimation on the one hand, and patient satisfaction on the other.

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In case of choledocholithiasis, EUS has the unique ability to directly visualize the cause of biliary obstruction and to evaluate and integrate ductal abnormalities. The necessary software is easily available and allows adapting the questionnaire to the conditions and needs of each municipality. The resolution is maintained in the thin optical system by an integrated design of the encoding scheme, the process of making the coding elements, and the decoding algorithms. Guard-band influence on orthogonal-band-multiplexed coherent optical OFDM. Public reporting of clinical outcomes of assisted reproductive technology programs: implications for other medical and surgical procedures.

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There has been an increase in adolescent substance use that has led to the development and implementation of prevention programs. Our data indicate that activation of the p38 MAP kinase pathway plays a central role in the oxidant-induced inhibition of insulin-regulated glucose transport, and unveils an important biochemical link between the classical stress-activated and insulin signaling pathways in skeletal muscle. Expanding the knowledge of the molecular mechanisms underlying MI is of profound importance to developing a cure for MI.

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Our meta-analysis brings weak support towards an efficacy of low dosages of baclofen on the maintenance of abstinence in alcohol-dependent patients. Using photoluminescence, scanning tunneling spectroscopy, current-sensing AFM measurements in single QD-DNA cascade constructs, and temperature-dependent ensemble devices using TiO2 nanotubes, we show that Dexter energy transfer, likely mediated by the exciton-shelves formed in these QD-DNA self-assembled structures, can be used for efficient transport of energy across QD-DNA thin films. Biocompatibility of poly(D,L-lactide-co-glycolide) nanoparticles conjugated with alendronate. The abnormal oocyte phenotype is characterized by instability, as shown by the loss and reappearance of the abo maternal effect under specific genetic conditions.

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We recently reported that hepatocyte growth factor (HGF) induces EGFR-TKI resistance by activating MET that restores downstream mitogen activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK)1/2 and phosphoinositide 3-kinase (PI3K)/Akt signaling. ATP-binding proteins, including protein kinases, play essential roles in many biological and pathological processes and thus these proteins are attractive as drug targets. A novel algorithm for the determination of bacterial cell volumes that is unbiased by cell morphology. Thus, these data suggest that paraneoplastic CS per se was involved in the pathogenesis of hypophosphatemia.

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Variable parameters within the presented matched pairs design are the number of used matching criteria as well as minimum drug consumption limit relevant for the classification in PCGs. Baseline DM2 laboratory data were compiled representing 68 different types of laboratory tests and 1442 total studies.

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Prediction of cardiovascular disease risk using waist circumference among Aboriginals in a remote Australian community. In both tasks, participants were tested with upright and inverted faces. These data, and DNA sequencing analyses reported previously revealed that the UL1 gene: (1) contains a major open reading frame (ORF) of 258 amino acids, (2) is a homologue of the ORF2 gene of varicella zoster virus (VZV), (3) is conserved in the genome of DIPs of EHV-1, (4) encodes a 1.2-kb early (E) mRNA that is transcribed toward the short region of the genome, (5) utilizes a transcription initiation site approximately 1,120 nucleotides from the L-terminus, and (6) utilizes a transcription termination site approximately 2211 nucleotides from the L-terminus. Percutaneous tibial nerve stimulation (PTNS) and sacral neuromodulation (SNM) are currently the two approved methods for delivering this therapy. We recommend applying the FMBU-A when assessing bone health in children with CP.

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Diagnosis can be made with the assistance of computerized tomographic scanning, but transfer of planning to the surgical field is limited. In accordance with our hypothesis significant differences between the species were apparent during both learning and memory trials with the social species exhibiting superior performances. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.

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Since the early reports on the incidence of mechanical complications of acute myocardial infarction (AMI) assessed by echocardiography published in the 1980s, the management of patients with AMI has changed considerably, in particular with the progressive development of early revascularisation. Weight of testis and accessory sex organs of nicotine treated group was significantly reduced.

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Acquisition of conditioned taste aversion in rats is mediated by ipsilateral interaction of cortical and mesencephalic mechanisms. Whereas purifying selection has been suggested in mammalian TLR9, evolutionary features of TLR9 in teleosts have not been investigated in detail. We suggest that evidence-based assessment of value has restricted the availability of medicines in Australia in a way that reflects the relative bargaining power of government and the pharmaceutical industry. More fundamental and prospective research is necessary to clarify their clinical value. The value of a drug: from innovation to the payment via Karl Marx.

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In this article, the mechanisms of Al neurotoxicity are reviewed and recommendations are put forth with regard to future research. Effectiveness of salmon calcitonin nasal spray preparation in migraine treatment.

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Predicting breast screening attendance using machine learning techniques. This diversity is not just simple noise but has biological relevance by generating plasticity. A 58-year-old female with a diffuse large cell lymphoma stage IV receiving cyclophosphamide, doxorubicin, vincristine, and prednisone. All women with karyotypes of chorionic villi isolated from first trimester spontaneous miscarriages at the time of dilation and curettage from 1999 to 2006. With the increasing consumption of herbal products intended to promote better health, it is extremely important to assure the safety and quality of herbal preparations.

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Importantly, we summarized the intrinsic neuronal determinants for neurite growth such as cAMP, PTEN/mTOR, APC-Cdh1, KLF4, etc., the mechanisms underlying development-dependent decline of CNS neurons growth ability, and procedures to enhance the intrinsic growth potential. Previous studies have indicated that administration of chemically modified, low-anticoagulant heparins prevents some of the morphologic and physiologic alterations occurring in experimental diabetic nephropathy. The present study investigated the effects of sonification pulse rate and sensor reliability on operator trust and mental workload.

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The results from this research highlight that greater action is required to improve patient safety in mental health settings. We also tested for potential threshold effects by considering studies that included measurement cut-points that met intake levels recommended by the American Heart Association. Multivariable analysis was performed to identify risk factors associated with disease progression. White matter tractography in bipolar disorder and schizophrenia. Submaximal, but not maximal, exercise testing detects differences in the effects of beta-blockers during treadmill exercise: a study of celiprolol and atenolol.

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The COBAS Ampliprep extraction system is comparable to the MagNA Pure and offers a high reliability for extracting EBV DNA from whole blood. By Northern Blot analysis we detected a 800 bp long product, and by immunoaffinity we detected in sputum and in cultured epithelial cell supernatant (NCI-H322 cell line) a 12 kD protein species cross-reacting with anti-elafin IgG.

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Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive poly-L,D-lactide spiral partial ureteral stent: an experimental study. Vascular and electromyographic responses evoked in forearm muscle by isometric contraction of the contralateral forearm.

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Anion permeation in an apical membrane chloride channel of a secretory epithelial cell. We report a case of benign mesothelial cell inclusions in cervical lymph nodes, which was associated with chylous effusion, and immunohistochemistry revealed unusual weak cytoplasmic epithelial membrane antigen positivity in the cells. At the posterior part of the tongue, filiform papillae were totally diminished and their epithelium was parakeratinized. The drugs were commercially available preparations of prostaglandins, beta-blockers, alpha-2 agonists, and carbonic anhydrase inhibitors given for 7 days in a manner similar to that used in humans. The clinical course was characterized by rapid deterioration, with a mean period of 16 days from onset of fever to death.

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We conclude that this patient developed argyrosis of the urinary tract, and review previously published papers concerning complications of silver nitrate instillation. The effect of intra-urethral catheter for prostatic hypertrophy patients who are unfit for operation and suffer from urinary retention

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Immunoelectron microscopic localization of herpes simplex virus glycoprotein D in infected culture cells using the indirect peroxidase-labeled antibody method After five years, cancer-free patients operated on for low or very low rectal cancer have a better QOL if a definitive terminal abdominal stoma was avoided.

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Flame retardants at the top of a simulated baltic marine food web--a case study concerning African penguins from the Gdansk Zoo. Minimal changes were seen in kinematics and kinetics with the addition of shoes. The interaction could, unpredictably, result in either enhancement or suppression of the immune response to conjugate vaccines if they are injected soon after or concurrently with diphtheria or tetanus toxoid. Effects of proton motive force on the structure and dynamics of bovine cytochrome C oxidase in phospholipid vesicles.

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In mammals, this takes place during postembryonic development, a period around birth when the T3 level peaks. The effect of topical and systemic administration of 3-hydroxykynurenine (3HK) on orthotopic murine corneal allograft survival was examined. Evaluation of an expert system provides unique challenges in an organizational setting. Knowledge and beliefs about elephantiasis and hydrocele of lymphatic filariasis and some socio-demographic determinants in an endemic community of Eastern India.

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Wellington HEMS offers advantage over the road ambulance when dispatched and utilised appropriately. This study was randomized, double-blind, placebo controlled study. Judicious dosing of anti-angiogenic treatment can transiently normalize the tumor vasculature by decreasing vascular permeability and improving tumor perfusion and blood flow, and synergize with immunotherapy in this time window.

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Phasic synaptic remodeling of the rat arcuate nucleus during the estrous cycle depends on insulin-like growth factor-I receptor activation. The aim of this study was to examine whether bilirubin may explain the high incidence of vascular complications in haemodialysis patients with Type 2 diabetes.

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Consistent with these findings, dominant negative Cdk1 protein significantly reduced FoxM1B transcriptional activity and inhibited FoxM1B recruitment of the CBP coactivator protein. Pulpotomy procedure was performed, and the radicular pulp tissue of one molar capped with A. The intervention group will receive web-based CBT, consisting of three F2F sessions and maximally eight web-based modules over a period of 6 months.

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Results add to the evidence that distinguishes express and regular direction errors and underline that the complex requirements of the AST are reflected in a comparatively rich set of non-redundant parameters. Two monoclonal antibodies were produced against protein antigens of Salmonella typhi.

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Obesity has been shown to be associated with atrial enlargement and ventricular diastolic dysfunction, both of which are risk factors for atrial fibrillation (AF). Provision of fluoride varnish treatment by medical and dental care providers: variation by race/ethnicity and levels of urban influence. This paper presents the results of studying the interaction of ketamine with ACh in two animal species. Interval-specific Ch10 congenics containing the susceptibility locus on distal Ch10 also demonstrated susceptibility to pilocarpine-induced seizures, confirming results from the F(2) mapping population and strongly supporting the presence of a QTL between rs13480781 (117.6 Mb) and rs13480832 (127.7 Mb). Balancing selection preserves variation at the self-incompatibility locus (S-locus) of flowering plants for tens of millions of years, making it possible to detect demographic events that occurred prior to the origin of extant species.

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A cross-sectional study was conducted to investigate the association between breastfeeding behaviour and exposure to environmental tobacco smoke (ETS). Acute fulminant hepatitis B during hepatitis C virus therapy with direct-acting antivirals in a patient co-infected with HIV.

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Our intention is to help review authors in any field to set eligibility criteria for studies to include in a systematic review that relate directly to the intrinsic strength of the studies in inferring causality. For laparoscopic surgery, dexmedetomidine infusion did not provide any analgesic benefit.

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The dimensionality of extracted features can be greatly reduced by the principle component analysis (PCA) algorithm before the most discriminative features selected are fed into a SVM classifier with the radial basis function (RBF) in order to separate epileptic seizure from seizure-free EEG signals. These measurements indicated that the number of immature T cells expressing TdT in the intestinal epithelium was less than one cell per 10(7) lymphocytes.

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Later, the polygonal epithelial cells of the outermost layer show cyclic stages of necrosis and sloughing followed by their regeneration and repair. Nutritional status and oral status of the elderly with dementia: a 2-year study.

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Good tolerability of high dose colistin-based therapy in patients with haematological malignancies. Analysis of membrane rigidity showed that parameters describing bacterial elastic properties underwent waveform changes: the decrease in bacterial elasticity (from day 1 to 6) was followed by its increase on day 12 in culture.

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Contribution of facial feature dimensions and velocity parameters on particle inhalability. We will present a clinical case of a patient with an ischemic stroke while on dabigatran that was found with low dabigatran plasma levels and we will discuss the currently available data on the effects of inherent patient characteristics on dabigatran pharmacokinetics, the clinical impact of dabigatran plasma levels on safety and efficacy as well as the possibility of improving the risk-benefit profile of this agent by tailoring the dose for selected patient groups. Normal swallowing acoustics across age, gender, bolus viscosity, and bolus volume.

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This result indicates that during their evolutionary histories the proteome-scale evolutionary patterns associated with prokaryotes exposed to low temperature environments were distinct from the proteome-scale evolutionary patterns associated with prokaryotes exposed to high temperature environments in terms of changes in amino acid composition of the proteins. Feulgen-microspectrophotometric determination of different evolutionary patterns in serial cultures of cells derived from human skin tumours.

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While zinc intake is associated with lower risk of obstructive lung disorder, the role of smoking cession and/or prevention are likely to be more important given their far greater effect on respiratory risk. The percentage of mucosal volume occupied by parietal cells (volume density) and the number of parietal cells per unit volume of gastric mucosa (numerical density) increased significantly 3 days after birth in the cardiac and body regions, but not in the pyloric region, of the stomach. Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group. We evaluated how the duration of cold ischemia influences the cold ischemic injury. From the analysis of vibrational modes, we observed that the changes are mainly due to the nitro and amino groups.

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Moreover, identity of the SopE/pTZ57R/T product was confirmed by restriction enzyme digestion assay and sequencing. Effects of prostaglandins, cAMP, and changes in cytosolic calcium on platelet aggregation induced by a thromboxane A2 mimic (U46619). I/R injury produced significant increases in aminotransferase, ADMA, eNOS, and iNOS, but decreases in Arg and Arg/ADMA levels.

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RNA hybridization studies show that CKS-17 inhibits SEB-induced TNF-alpha mRNA accumulation in human peripheral blood mononuclear cells and human monocytes. Prothrombotic and vascular risk factors in nonarteritic anterior ischemic optic neuropathy. However, toxicity was prodigious, and an emphasis of future research should be to decrease toxicity.

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To examine visual and verbal coding strategies, I asked children with intellectual disabilities and peers matched for MA and CA to perform picture memory span tasks with phonologically similar, visually similar, long, or nonsimilar named items. This is especially important when the organism involved is relatively uncommon and little is known about its diversity and distribution. This has led to a search for safer alternatives, one of which, the recently identified depolymerized holothurian glycosaminoglycan (DHG), causes less bleeding and exhibits a better antithrombotic-hemorrhagic ratio in rats and dogs than UFH and low-molecular-weight heparin (LMWH). Short-term results suggest that subconjunctival bevacizumab is well tolerated but does not cause regression of corneal vessels in recurrent omeprazole dr 40 mg cost cvs pterygium. The new housing systems allow for the expression of highly-motivated behaviors.

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Neocortical ODI outperformed cortical thickness and white matter fractional anisotropy for the prediction of chronological age in the same individuals. Upon closer analysis, the frontal lobe dysfunction has been verified by the demonstration of reduced blood flow in frontal areas in these patients. P-wave morphology is unaffected gabitril vs gabapentin 100 by training-induced biatrial dilatation: a prospective, longitudinal study in healthy athletes. Specific patterns of acetylation of the core histones are associated with specific structures and functions of chromatin.

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A summary of the current knowledge about classical Hodgkin Lymphoma focusing on the cross-talk between tumor cells and precio clavinex duo forte chile the microenvironment leading to immune-escape, angiogenesis tumor growth/survival and drug resistance will be reviewed here. Sixteen subjects smoked a water pipe on a clinical research ward. Analysis of BRAF mutation and extracellular regulated protein kinases activation in nasal mucosa melanomas Thirty-six rabbits were randomly divided into inflammatory and tumor groups.

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A total of clavamel forte augmentin uses 2067 elderly persons were then screened with a vernacular adaptation of the MMSE. CD59 is a natural membrane-bound inhibitor of the cytolytic complement membrane attack complex (MAC). And any lesion residue may be assessed immediately with postoperative DSA. Assessment of the value of MR imaging for examining patients with angiographically negative subarachnoid hemorrhage. Psychometric evaluation of the Swedish language Person-centred Climate Questionnaire-family version.

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The prevalence of diabetes in women of childbearing age is increasing. While this view has strong empirical and theoretical support, it is increasingly appreciated that QS under natural conditions may be incapable of monitoring bacterial numbers and, furthermore, that QS is evolutionarily unstable owing to conflicts of interest among competing cells. Infantile onset spinocerebellar ataxia with sensory neuropathy (IOSCA): neuropathological features. This review provides updated information about the use of opioids for the treatment of BTcP, with special emphasis akorazol cream 2% uses for vagina herpes on the use of new rapid onset opioids (ROOs).

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Interrelations between variables were assessed using Pearson correlation coefficients and stepwise regression analysis. Electron microscopy revealed two distinct populations of zymogen and neuroendocrine granules. Increased vitamin D supplementation recommended during summer season in the gulf region: a counterintuitive seasonal effect in vitamin D levels in adult, overweight and obese Middle Eastern residents. Functional lansoprazole 30mg capsuleas para q se usa reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. Relationship between distribution of binding sites and mRNA for DAARPP32 in the human brain.

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Fifteen databases were searched for qualitative research published between 1965 and June 2009, investigating the lived experience of recovery following TBI acquired during adulthood. In this article, we discuss how techniques issued from recent research in robotics can be applied to this filtering. Data were collected using a pretested, self-administered questionnaire, which was distributed in an examination setting and collected on the same day. Thus, a series of PS-tags that possess this unusual feature, especially the peptides PS19-6 (RIIIRRIRR) and PS19-6L (RLLLRRLRR), are potential candidate affinity peptide tags for gabax review and herald site-specific immobilization of proteins onto hydrophilic PS plates, which show potential as solid supports for protein-based biochips.

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Remineralization is the process by which hydroxyapatite (HAp) is restored in enamel cluvax forte instruccion subsurface lesions, and transversal microradiography (TMR) has been used to analyze remineralization in terms of the recovery of mineral content. Diagnostic signs on imaging may help to rapidly distinguish the cause of pituitary deficiency in patients with HIV infection.

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