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Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology. Birds living in radioactively contaminated areas use dietary antioxidants to cope with the damaging effects of radiation, but females also allocate dietary antioxidants to eggs, potentially enforcing a physiological trade-off between self-maintenance and reproductive investment. A majority of the responders experienced encounters with SIOs as positive. denniae species groups occupy the Afromontane Biotic Zone, found in various mountain systems to the south and east of the Congo Basin.

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For highly selected patients interstitial brachytherapy is introduced as an alternative surgically performed treatment option. Also, according to this phylogeny, all of the New World Blepharida species that feed on Bursera (Burseraceae) form a single monophyletic clade, with the Afrotropical species forming its sister clade. There appears increasing doubt about the use and safety of vaccinations. The status of the chondral implant was evaluated with the modified MOCART scoring scale. membrane, only the group incubated with H1152 developed significantly longer neurites.

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Reproducible and accurate results are presented for pure water samples containing typical concentrations of anions as well as for more specific types of samples, such as water compositions in the primary and secondary circuits of a nuclear power plant. Fifty patients were randomly selected from women who underwent breast reconstruction surgery at University of Michigan hospitals between July 1989 and May 1993. These data underscore the loss of tumor suppressive pathways and activation of specific oncogenic mechanisms associated with osteosarcoma oncogenesis, while drawing attention to the role of RUNX2 expression as a potential biomarker of chemotherapy failure in osteosarcoma. Further attention is given to laboratory diagnosis of syphilis and false-positive and false-negative serologic reactions.

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This association was not caused by any somatic confounding in these young, healthy men. We surveyed vaccine age-eligible women as part of the Victorian Population Health Survey 2011-2012, a population based telephone survey, to ascertain self-reported vaccine uptake and reasons for non-vaccination or non-completion of vaccination among young women resident in the state of Victoria, Australia. Multipoint linkage analysis and haplotype analysis indicate that the MCDR1 gene is in the 1.1-centimorgan (cM) interval between the genetic markers D6D249 and D6S1671, with a maximum LOD score of 40.03.

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In fact, high molecular weight c-myc RNA species were found to have accumulated in antisense-treated KYO1 cells. This systematic review identified an absence of reliable evidence describing positive effects of orthodontic treatment on periodontal health. Significant clinical side effects, including cardiac toxicity and myelosuppression, severely limit the therapeutic index of this commonly used agent and methods which improve doxorubicin efficacy could benefit many patients.

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This treatment modality warrants additional investigation in a phase III setting. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.

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This paper is concerned with the robust optimal tracking control strategy for a class of nonlinear multi-input multi-output discrete-time systems with unknown uncertainty via adaptive critic design (ACD) scheme. To study the efficacy of verteporfin photodynamic therapy (VPDT) retrospectively in the treatment of idiopathic subfoveal choroidal neovascularization (ICNV) in an Asian population in correlation with number of treatments and age at treatment.

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It is this potential for sequential generations in the mollusc that may be the key to understanding the complex transmission and life cycle patterns in the Digenea. Instrumental and tactile biofeedback is effective for reinforcement of normal flow patterns during speech tasks.

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Is heparin reversal with protamine after carotid endarterectomy dangerous? Mucins are major epithelial luminal surface proteins and function as a physical and biological barrier protecting mucous epithelia. Relatively high DHEA and DHEA-S (DHEA/S) levels were found to be associated with larger pituitary gland volumes. Here we present an analysis of Nedd4-null mice to show that loss of Nedd4 results in reduced insulin-like growth factor 1 (IGF-1) and insulin signaling, delayed embryonic development, reduced growth and body weight, and neonatal lethality.

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ESMO Clinical Practice Guidelines on palliative care: advanced care planning. Although faced with initial conflicting data particularly in steroid-refractory patients, two large, placebo-controlled trials have shown that intravenous infliximab induces and maintains clinical improvement in a clinically significant proportion of patients when used with scheduled re-treatment.

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Procalcitonin samples were obtained at three time intervals: as close to the time of the initial culture as possible (up to 12 hr after) and 24 and 72 hours after the initial culture. Starving adenine auxotrophic strains for adenine leads to a drastic increase of the enzymatic activity while adenine represses this activity.

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In addition, the effect of various bulking agents on spore survival was studied and dextran 4 was selected to enhance the physical properties of the lyophilized products. Central nervous system malformations and white matter changes in pseudo-neonatal adrenoleukodystrophy.

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A micro-architecturally biomimetic collagen template for mesenchymal condensation based cartilage regeneration. The application of currently available modeling approaches to human and animal metabolic pathway modeling is problematic because of multicompartmental cellular and tissue exchange of metabolites operating on many time scales. Inflammatory bowel disease (IBD) is a chronic and relapsing disorder which leads to an inflammation of the gastrointestinal tract.

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To determine the feasibility of visualization of the uvula and the soft palate during routine two-dimensional (2D) ultrasound examination and to develop a sonographic procedure that facilitates prenatal detection of isolated fetal cleft palate. The TEWL values of the facial test sites were higher compared to forearm values and did not correlate with the forearm. Simultaneous vitality and DNA-fragmentation measurement in spermatozoa of smokers and non-smokers.

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Implementation of a T4 extraction control for molecular assays of cerebrospinal fluid and stool specimens. This study aimed to evaluate the technical feasibility and safety of VAT for CMG.

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Can--and should--what you do on social media cost you your career? The present review will focus on the normal regulation of beta-cell mitogenesis and hormones production in vitro and in vivo, and furthermore, will present evidence for an insufficient extent of beta-cell regeneration in different forms of diabetes mellitus.

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The transition states were estimated and optimized from the reaction coordinates obtained by constraining and increasing the C10-C19 bond lengths. We retrospectively analyzed 17,323 consecutive angiographies from January 1st, 1984 to December 31st, 2003.

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Therapeutic exercise may help maintain or slow down the rate of decline in muscle mass and physical function that occurs with cachexia. Effect of spironolactone on the risks of mortality and hospitalization for heart failure in pre-dialysis advanced chronic kidney disease: A nationwide population-based study. Generalized estimating equations were used to analyze relationships between changes in energy prices and subsequent changes in hospital patient outcomes measures for the years 2008 through 2014. This article employs a neural-network based approach to improve psi prediction by taking advantage of angle periodicity and apply the new method to the prediction to phi angles. However, one arctic fox cub with a neurological disorder had pathological and serological evidence of encephalitozoonosis.

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This mixed-methods study (1) developed and psychometrically tested a brief self-administered tool with low literacy demands to identify negative ICS beliefs and CAM endorsement and (2) evaluated the clinical utility of the tool as a communication prompt in primary care. In this study, we aimed to identify gene markers that are relevant to both the occurrence and severity of toxicity symptoms.

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Clinical evaluation of the xDP output compression strategy for cochlear implants. The extent and boundaries of the roof, or pallium, of the telencephalon in lungfishes have been debated for over 30 years, and two hypotheses exist. Second, only one study included systematic tests of measurement invariance based on confirmatory factor analyses (CFA), and this study did not consider the higher-order factor structure of depression, although it is the CES-D global scale score that is most often used in the context of epidemiological studies. Transformation of mouse cells infected with AKR leukaemia virus induced by smog extracts. A second class of endo-siRNAs may enforce repression of mobile genetic elements, acting together with Piwi-interacting RNAs.

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The impact of female obesity on the outcome of fertility treatment. Gel filtration revealed that the activities in Peak 1 and Peak 2 had molecular weights of 170,000 and 600,000, respectively. All of the mutations affected the expression of an LCMV minigenome and the infectivity of virus-like particles, but to greatly varying degrees.

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Expanding the mouse embryonic stem cell proteome: combining three proteomic approaches. This is the first report of induction of BrdU-inducible fragile sites in the genome of the domestic dog. Airborne scattering of Cryptomeria japonica pollen depends on climate.

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The decreased miR-638 expression was more prevalent in non-TNBC compared with TNBC cases. The ASRS-AP and ASRS-AP-S showed high internal consistency and concurrent validity in relation to total K-SADS ADHD symptom severity score.

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The roles of diagnostic imaging (particularly magnetic resonance imaging) in adequate preoperative evaluation and staging and the fundamental principles of surgical management are discussed. Upon reapplication, they all showed the same tachyphylaxis pattern, reaching half the initial contraction.

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CTnDOT encodes an integrase that is a member of the tyrosine recombinase family. Results of the modeling were compared with the experimental kinetics measured in chloroplast thylakoids. MS-like brain lesions were assessed by T1-weighted, T2-weighted, and magnetization transfer MRI as well as by diffusion tensor imaging (DTI). Baicalin was extracted by using organic extraction methods and the purity was analyzed by high-performance liquid chromatography (HPLC). Electrospinning was used to fabricate a double layer nanocomposite nanofibrous mat consisting of an upper layer of poly(vinyl alcohol) and chitosan loaded with silver nanoparticles (AgNPs) and a lower layer of polyethylene oxide (PEO) or polyvinylpyrrolidone (PVP) nanofibers loaded with chlorhexidine (as an antiseptic).

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The assay was validated on three genetically related MDA231 human mammary carcinoma cell lines: wildtype, overexpressing DT-diaphorase (DT1), and overexpressing cytochrome p450 reductase (R4). Special techniques such as immunocytochemistry and electron microscopy have provided information that has resulted in refinement of diagnostic and conceptual issues.

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Antivirals acting upstream of RSV polymerase activity (i.e., compounds targeting the fusion protein or the nucleoprotein) reduced viral load immediately postinfection and partially attenuated interferon responses. More carbonaceous DBPs (C-DBPs: THMs, HAAs, CSs and HKs) and nitrogenous DBPs (N-DBPs: HANs and TCNM) were formed in chlorination than chloramination. The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin. Behavior determinants among cardiac rehabilitation patients receiving educational interventions: an application of the health action process approach. Validity was assessed by comparison with results from physical examination assessments of workers and self-reports of workers seeking medical care.

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History of Biochemistry at the University of Geneva From the Boulevard des Philosophes to Quai Ernest-Ansermet. History, physical findings, and image examination findings common to the two cases were analyzed to elucidate pathogenesis of hypertrophic osteoarthritis in the atlantodental articulation.

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Liposomes containing Ch-PEG27-CH2-triazole-TEG-(18)F revealed a hydrodynamic radius of 46 nm, liposomal Ch-PEG30-hbPG24-CH2-triazole-TEG-(18)F showed a radius of 84 nm and conventional liposomes with (18)F-cholesten 204 nm, respectively. Furthermore, IE2 was found to interact with the SUMO-modified form of TATA-binding protein (TBP)-associated factor 12 (TAF12), a component of the TFIID complex, in a SIM-dependent manner, and this interaction enhanced the transactivation activity of IE2. In summary, this work describes the direct, positive effect of PIF on the control of human trophoblastic cell invasion by modulation of MMP/TIMP balance and integrin expression. This study examines whether cardiopulmonary bypass affects conduit-dependent outcomes of coronary artery bypass grafting (CABG) surgery.

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On intestinal polyposis in rats developed under the influence of radioactive cerium A 2.2-kilobase cDNA clone for human arylsulfatase B (ASB) and several genomic clones were isolated and sequenced. The application of a primary tracheal anastomosis is not always feasible. An assessment of the quality of methodology of the studies found most used weak designs and poor methodology, with a tendency for higher quality studies to produce negative results.

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Pax6 and its Drosophila homolog Eyeless (Ey) play essential roles during eye development. Because of the high prevalence of reduced bone mineralization reported in numerous studies including this study, routinely screening for reduced bone mineralization is warranted in patients receiving anticonvulsant therapy.

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To investigate how basic aspects of perception are shaped by acquired knowledge about the world, we assessed colour perception and cognition in patients with semantic dementia (SD), a disorder that progressively erodes conceptual knowledge. Changes in sleep macrostructure may have an impact in the impairment of cognitive functions of patients suffering from anxiety or depression. Gene delivery into hepatocytes with the preS/liposome/DNA system. A description of the proposed mode of action of these medications and the most relevant studies is included.

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However, the mechanism responsible for this adverse effect is not readily apparent. The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. The immunoregulatory roles of natural killer T cells in cyclophosphamide-induced tolerance. Intravesical instillation of amikacin for treatment of a lower urinary tract infection caused by Pseudomonas aeruginosa in a dog.

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We conclude that by avoiding full sternotomy, the approach of minimal surgical access contributes to an improved postoperative stability of the chest and less surgical pain. The major TIV DNA components, L (greater than 174 kbp) and S1 (10.8 kbp) that are found in virions in approximately equivalent amounts, were made in both infected cell lines.

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Myopathy is particularly concerning because of the potential for rhabdomyolysis and death. Morphine-6-glucuronide and morphine: mu-opioid receptor binding and effects on dopamine-sensitive adenylate cyclase in striatum. We report a new case in which pulmonary microvascular cytologic study allowed a definite diagnosis of fat embolism syndrome. These findings represent further evidence of the association between factor H dysfunction and HUS.