Pulmocef axetil is an orally active prodrug of Pulmocef. After oral administration, Pulmocef axetil, as Pulmocef, is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release Pulmocef into the blood stream. Conversion to Pulmocef, the microbiologically active form, occurs rapidly. The inherent properties of Pulmocef are unaltered after its administration as Pulmocef axetil. Pulmocef exerts its bactericidal effect by binding to an enzyme or enzymes referred to as penicillin-binding proteins (PBPs) involved in bacterial cell wall synthesis. This binding results in inhibition of bacterial cell wall synthesis and subsequent cell death. Specifically, Pulmocef shows high affinity for PBP 3, a primary target for Pulmocef in gram-negative organisms such as E. coli.
Other names for this medication:
Cefuroxime,
Ceftum,
Zocef,
Cefakind,
Supacef,
Altacef,
Oratil,
Stafcure,
Pulmocef,
Zefu,
Ceftin,
Kefurox,
Zinacef,
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