Makrodex is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Makrodex is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss. Makrodex is available under several brandnames. Makrodex is not available in the United States. Makrodex is available in Australia, Israel and New Zealand. Makrodex has also been tested to possess antimalarial activity. Makrodex prevents bacteria from growing, by interfering with their protein synthesis. Makrodex binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Makrodex has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.
Other names for this medication:
Roxithromycin,
Rulide,
Biaxsig,
Ixor,
Makrodex,
Nirox,
Overal,
Remora,
Renicin,
Romac,
Roxithromycine,
Rulid,
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