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Letop (Topiramate)

Letop is an oral drug that is used to prevent the seizures of epilepsy. It is an anti-epileptic or anti-seizure drug. It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Letop also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although Letop's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, Letop may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that Letop may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved Letop as a tablet in 1997. The sprinkle capsules were approved in October 1998.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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The Tuskegee Legacy Project Questionnaire, which focused on research subject participation, was administered in two different surveys (1999-2000 and 2003) in seven cities. There was no obvious regional division for construction cement dust profiles. S(H)2 reaction vs hydrogen abstraction/expulsion in methyl radical-methylsilane reactions: effects of prereactive complex formation.

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However, HPV genotyping using formalin-fixed, paraffin-embedded (FFPE) tissues is technically challenging. We hypothesised that production of circulating aldosterone (ALDO) would be suppressed to a greater extent in subjects treated with an ACE-inhibitor of higher tissue avidity. Here, we present a noninvasive method to image subcellular structures in live cells using bioconjugated QD nanocomposites. The relative Kcat/KM ratio for EtOH-fed to that of pair-fed microsomal aniline hydroxylase from NADPH plus O2-, t-BuOOH-, and CumOOH-dependent reactions were 1.5, 7.4, and 1.2, respectively.

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A validated 181-item FFQ was applied retrospectively, after delivery, to assess the maternal diet during the 8th month of pregnancy. On final pathologic examination, all margins were free of tumor. Although result of immunofluorescence is similar, 88R protein was not detected in viromatrix. Influence of varying level terrain on wheelchair propulsion biomechanics.

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To elucidate photosensitization potentials of new quinolone antibacterial agents, production of active oxygen species and peroxidation of squalene after ultraviolet A exposure were investigated. The aim of this study is to evaluate the role of real-time polymerase chain reaction (PCR) and conventional bacterial culture methods in the detection of Pseudomonas aeruginosa in contact lens-induced severe, partially treated corneal ulcers referred to a tertiary center. Synthetic musk toxicity to early life stages of zebrafish (Danio rerio). Investigators and participants were unaware of the treatment allocation status.

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A significant number of patients with cystic fibrosis who received repeated courses of aminoglycosides showed alterations in High Frequency Audiometry and Distortion Product Otoacoustic Emissions. Studies on methods for the phage-sensitivity test of acid-fast bacteria. Provincial malaria epidemiological data (2004-2007) collected by the health posts in 23 provinces were used in conjunction with space-borne observations from NASA satellites.

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We illustrate these ideas by considering photodissociation of formaldehyde. The effect of TNF-alpha and IL-6 on the permeability of the rat blood-retinal barrier in vivo. 48 h prior to CASP surgery, AM of female C57BL/6 mice were selectively depleted by intratracheal application of clodronate liposomes (Lipo-clod). Progestin receptors in substance P-immunoreactive neurons in the hypothalamus of male guinea pigs after behaviorally effective estradiol pulse treatment.

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Evaluate the effect of Meglumine Antimoniate on maternal-fetal transference in F1 generations (offspring of dams exposed to the drug), and embryotoxicity in F2 generations. We report a 54-year-old CD patient with EATL revealed by subacute polyradiculopathy.

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The aim of this pilot study was to determine whether 3D sphincter volume can be correlated with the area under the UPP curve. Department of Otolaryngology-Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, a tertiary care centre in China. This article reviews the factors that should be considered in the selection of an initial antiretroviral regimen and present the currently available evidence regarding the status of individual antiretroviral agents and treatment strategies relative to these factors. Benchmarking by cross-institutional comparison of student achievement in a progress test. Urea formation, cell number, cellular protein content and tyrosine transaminase activity were not changed by PCB addition in cultured rat hepatocytes.

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Anxiety and depressive symptom levels, attachment pattern, and parental attitudes of mothers and social-emotional problems and developmental level of the toddlers were explored to assess possible confounding factors in the mother-toddler relationship. The dysplastic corneal epithelium is characterized by the abnormal proliferation of epithelial cells.

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Supportive management was instituted in the intensive care unit (ICU). Two children with motor delay and hypotonia were treated with oral prednisone for 3 months with no clinical improvement. Seven were exclusively French speaking and seven bilingual (French-Portuguese, Arab, Turkish, or Serbo-Croatian) children. The bacterium Pseudoalteromonas tunicata is a successful competitor on marine surfaces owing primarily to its ability to produce a number of inhibitory molecules.

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A new classification for retrospective reviews of medical records. bovis sera, 5 were recognized by the anti-MPB-70 monoclonal antibodies, and one monoclonal antibody, SB10, recognized all 5 clones. Preclinical observations made with tiludronate, like with other bisphosphonates, were predictive of results obtained in clinical investigation.

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Given the prolonged time pediatric patients may remain enterally dependent, further quality improvement and education initiatives are needed to improve long-term care and outcomes of these patients. Diagnosis is best made by analysis and culture of synovial fluid.

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However, our data suggest that the majority of candidates participate in novel mechanisms to promote gcs-1 expression. Comparisons were made in the basal state and after carbachol-induced bronchoconstriction in seven New Zealand adult rabbits. Because frailty is a complex phenomenon associated with poor outcomes, the identification of patient profiles with different care needs might be of greater practical help than to look for a unifying definition. THPI in 12h urine ranged from MDL (5 ppb) to 640 ppb and was stable for at least one year. Spectral domain ocular coherence tomography of retinitis associated with Toxoplasma, cytomegalovirus, or varicella zoster virus demonstrates full-thickness disruption of the retinal architecture and overall thickening.

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Governmental regulations for early retirement by means of energy expenditure cut offs. The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. We investigated whether parametric, compared to nonparametric, analyses of ordered categorical data may lead to different conclusions.

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At surgery, a subscapularis tenotomy utilized to approach the shoulder. Transposition of great arteries with constrictive ductus arteriosus revisited. One patient went into cardiac arrest during the flight and died.

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After 5 days, mice were treated with a single dose of 40 or 55 mg/kg PTZ (acute paradigm) or 40 mg/kg PTZ delivered daily (kindling paradigm). Here, we report that FL HSCs use oxygen dependent energy generating pathways significantly more than their BM counterparts.

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PDK1(DeltaPOMC) mice initially display hyperphagia, increased body weight, and impaired glucose metabolism caused by reduced hypothalamic POMC expression. Measurement of MPOD is achievable with a wide range of techniques, which are typically categorized into one of two groups: psychophysical (requiring a response from the subject) or objective (requiring minimal input from the subject). The aim of this study was to examine whether the elevated serum-soluble (s) selectin levels are associated with RA or SSc. A conventional approach to reduce the oxygen demand of a culture is the fed-batch technology.

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Cancerostatic effect of alkylating compounds in relation to glycolytic activity of tumor cells in vivo This paper synthesizes research and theory on aspects of activities producing variations in perceived temporality and subjective experience. Asp226 bridges the base of the specificity pocket with its negative charge partially buried by interactions made with Ser190 and Tyr228. Over 31 000 adult and pediatric patients have been treated thus far. Digital tomosynthesis provided useful information in making the roentgenologic diagnosis of pulmonary lesions.

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The standard exercise prescription used for other chronic lung diseases is effective in ILD, including 8 weeks of training with at least two supervised sessions per week and at least 30 min of aerobic training per session. Interleukin 1 (IL-1) is an autocrine growth factor for normal keratinocytes and is capable of inducing bone degradation. Concentrations of chloramphenicol were determined in samples of serum and the rates of distribution and elimination extrapolated. The covalent modification of sulfhydryl groups by S-nitrosoglutathione has been examined using model compounds.

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Continuing education programs for practising pharmacists about the safety of different herbal products should be established in Kuwait. Alternate pathway 17,20-lyase enzyme activity in the adrenals is enhanced in patients with polycystic ovary syndrome.

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Growth of these tamoxifen-stimulated tumors can be inhibited with the pure antiestrogen ICI 164,384 upon withdrawal of tamoxifen. Cells use a limited number of host receptors and signaling pathways to both discriminate among extracellular and intracellular microbes, and also to generate responses commensurate to each threat. It was confirmed that MEKA is rapidly phosphorylated by adrenergic stimulation of pineal glands in organ culture. lactis HN019 could be internalized into the INT-407 cells and attenuated IL-8 mRNA level at both baseline and S.

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With the use of a rat inferior epigastric artery flap as an ischemia/reperfusion injury (I/R) model, we investigated whether exogenous NO donation regulates endogenous NO synthase (NOS) expression in the flap vessels and promotes flap survival. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms. Choice of type of phototherapy and close monitoring, with parental partnership, is the key to successful treatment.

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In contrast, polyamines had little or no effect on the linear or outwardly rectifying kainate responses of other interneurons or CA3 pyramidal cells in which GluR2 mRNA was routinely detected. Both the test meals fulfilled the requirement of neutrality as concerns a null effect on the breath 13CO2 profile. We propose that muscle tissue trauma results in an alteration in the patterns of neural recruitment, a reduction in the force-generating capability of the injured muscle, and/or pain sensations.

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Assessment of immunization against recombinant human bone morphogenetic protein-2 (dibotermin alpha) on reproduction and development in rabbits. However, the level of tyrosine-phosphorylated protein was decreased at 41 degrees C.

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Release of follicle stimulating hormone (FSH) from the rat pituitary in vitro due to the effect of potassium ions Furthermore, we propose the corresponding probabilistic model for joint temporal learning and feature learning. Autism is a serious behavioral disorder among young children that now occurs at epidemic rates in developing countries like India. We studied patients with proximal deep vein thrombosis (DVT) of lower limbs and recurrent pulmonary thrombo-embolism (PTE), who were put on permanent IVC filters for the prevention of further episodes of PTE.

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Prior analysis has shown that on satisfaction of some underlying assumptions, the landscapes are free of suboptimal traps that could halt the search for a global optimum with gradient-based algorithms. A processing work-flow for measuring erythrocytes velocity in extended vascular networks from wide field high-resolution optical imaging data. At 12:00 h, 1.0 or 2.5 mg/kg body weight of LPS was given via an i.v. However, this gene expression was greater in Yorkshire than Meishan pig on DG55.

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In the placenta villi cells from early and term gestation in vitro, both exogenous and endogenous hCG showed a stimulatory effect on progesterone secretion, and the effect was approximately proportional to the concentration of the exogenous hCG added. Therefore, this topic is at the heart of a number of biological and technological processes and thus remains of vital interest. Formerly called IFN-gamma-inducing factor, IL-18 is the new name of a novel cytokine that plays an important role in the TH1 response, primarily by its ability to induce IFN-gamma production in T cells and natural killer cells. Brain concentration of lactate, the end product of glucose utilization via glycolysis, varies as a function of sleep state, and like slow wave activity (SWA) in the electroencephalogram (EEG), increases as a function of time spent awake or in rapid eye movement sleep and declines as a function of time spent in slow wave sleep (SWS).

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The switch factor responsible for restoration of wild-type behaviour was isolated from membrane vesicle preparations. The results indicate that maintenance of cardiorespiratory fitness during middle age, when decline in fitness typically accelerates and risk of sleep problems is elevated, helps protect against the onset of sleep complaints made to a physician. The changes observed in the nucleus intercollicularis of males represent a morphological marker for the cellular actions of the steroid.

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Few data on mitochondrial toxicity of antiviral drugs are available in HIV-positive children. Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage.

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Caspase cleavage of the MET receptor generates an HGF interfering fragment. US examination of the appendix in children with suspected appendicitis: the additional value of secondary signs. The results showed that the changes of the properties of packed particles, bed height and liquid superficial velocity would cause the changes of velocity gradient (G) and reaction time (T). In parts III and IV of this series, three types of typical environmental complexants are studied: (a) simple ligands (OH- and C03(2-)), (b) fulvic or humic substances including many sites with broadly varying rate constants, and (c) aggregates including a broad range of sizes and diffusion coefficients.

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PspA-specific IgG but not IgA level was higher in the airways and blood of mice nasally administered a low dose of PspA plus poly(I:C) than in mice nasally administered PspA alone or poly(I:C) alone. The aim of this study was to combine the advantages and to reduce the disadvantages of acid hydrolysis and conventional enzymatic hydrolysis procedures.

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Mental illnesses and mental health have, out of ignorance and fear, evoked a low priority in healthcare systems the world over. The cognitive processes underlying differential time courses are discussed. In the meta-analyses comparing conventional clinical assessment plus central venous pressure monitoring with or without esophageal Doppler monitoring, statistically significant differences in total and major complications favoring the use of Doppler were found. As a pilot project to provide baseline data for a detailed evaluation of bleeding and thrombosis in the current era, extracorporeal life support patients were analyzed from eight centers in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network.

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Direct clipping with thrombectomy was performed successfully with an uneventful postoperative course. Monitoring of clindamycin urinary tract infection treatment cellular systems involved in inflammatory cascades of the innate immunity was successfully applied to the IL-1-driven CAPS diseases. When pyruvate/malate were used as substrates, H(2)O(2) release rate was lower in trained rats only in the presence of antimycin A. On gestation days 1-22, pregnant dams were fed either a vitamin fortified ethanol-containing liquid diet, pair fed a calorically equivalent sucrose-containing diet, or given rat chow ad libitum. Live bird markets (LBMs) provide an ideal environment for the evolution and interspecies transfer of avian influenza viruses (AIVs).

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Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during cell cycle progression. They combine the excellent chemical stability of synthetic polymer barriers with the strong adhesive properties of rispond plus drug protein-based complex coacervates, inspired by biological underwater glues.

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Tracheal cartilage regeneration and new bone formation by slow release of bone morphogenetic protein (BMP)-2. In the postnatal life, hematopoietic stem cell (HSC) niches are specialized microenvironments in the bone marrow that are essential for atomoxetine drug labeling the maintenance and function of HSCs. There has been neither laboratory finding nor histological feature diagnostic of PG, and diagnosis of PG is mainly made based on the exclusion criteria.

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Evaluation of colonic absorbability of drugs in dogs using a novel colon-targeted delivery capsule (CTDC). Ventriculoperitoneal shunt is an ideal option of vast majority of patients. Effects of the pharmaceuticals diclofenac and metoprolol on gene expression levels of enzymes of biotransformation, excretion pathways and estrogenicity in primary hepatocytes of Nile tilapia amoxicillin suspension dye free (Oreochromis niloticus).