Ledars have a broad spectrum of activity against many gram-positive and gram-negative bacteria as well as Mycoplasma, Chlamydia, Rickettsiae, Plasmodia, and amoebae. They are usually bacteriostatic. They are also active against Streptococcus pneumoniae. The Ledars are active against most gram-positive bacilli, including Actinomyces israelii, Arachnia, Bacillus anthracis, Listeria monocytogenes, and most clostridia and Nocardia. Many gram-negative bacteria are resistant to Ledars. Penicillin-sensitive Neisseria gonorrhoeae and meningococci are sensitive to Ledars, whereas penicillin-resistant gonococci tend to be resistant to them. Most community acquired E.coli, Xanthomonas maltophilia, and Pseudomonas pseudomallei are sensitive to Ledars, as are most vibrios, Campylobacter, Helicobacter, Pasturella multocida, Brucella, and some Haemophilus spp Klein and Cunha (1995).
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