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The data effectively exclude charge separation between the chromophore and a protein residue as the main mechanism for energy storage in the primary photoproduct and argue that the light energy is stored in the form of distortions of the bathorhodopsin chromophore. When all non-pharmacological factors and age-associated pharmacokinetics are taken into account, there is still no full explanation of the potentially altered drug action and increased drug toxicity observed in the elderly. Keratohyalin granules appear predominantly in the intermediate layer in the epithelium on the anterior side of filiform papillae. Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. In recent years, pesticide contamination of limited water resources has become a serious challenge worldwide.

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Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in cultured mouse embryo cells. The multifunctionality of nucleolin is linked to its tripartite structure, post-translational modifications and its ability of shuttling from and to the nucleolus/nucleoplasm and cytoplasm. The purpose of this study was to investigate whether melatonin could efficiently protect against neurotoxicity induced by nickel.

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The histopathological examination of the surgical specimen revealed an inflammatory myofibroblastic tumor including many histiocytes stained positively with CD 68. In this paper, we propose an active learning approach aimed at minimizing the user annotation effort: the user annotates only one desired extraction and then merely answers extraction queries generated by the system. The Assessment of Family Functions, Dyadic Adjustment, and Parental Attitude in Adolescents with Substance Use Disorder.

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Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury. A laboratory preparation mimicking human peptic ulceration: a chronic antral peptic ulcer postsection and reanastomosis at the antral-fundic junction in the rat. In clinical trials, what is sought is a measurement of change in the level of well being during the evolution of an illness or of the different levels that exist between two groups. Synovial fluid from patients with rheumatoid arthritis contains a unique inhibitor of interleukin 1 alpha.

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There is no higher rate of acute rejection during follow-up.Elevated blood lipids after conversion may be easily controlled. Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization. Furthermore, in this study, the specific attachment of DNA via gold-thiol bonds to Au nanoparticles is compared to nonspecific adsorption of DNA.

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Greater severity of symptoms prospectively predicted lower incontinence-specific quality of life (FI QLS lifestyle domain) and lower general quality of life (WHOQOL-BREF environmental domain). The study was conducted to assess pressure ulcer incidence in intensive care patients, the factors related to pressure ulcer incidence and the course of pressure ulcers after the admission to an intensive care unit. Transforming growth factor-beta (TGF-beta) triggers EMT via intracellular Smad transducers and other signaling proteins. The siRNAs are generated by cleavage of larger double-stranded RNAs (dsRNAs) and provide the sequence specificity for degradation of cognate RNA molecules.

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Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance. Many psychoactive drugs that have been studied in other patient populations are widely used to treat these deficits, but rigorous evidence of their efficacy in TBI is lacking.

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Acute exposure to ethanol causes paralysis at high concentrations in the nematode Caenorhabditis elegans. Pneumatic dry granulation has the potential to provide such alternatives.

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One expected effect of copper is peroxidation of lipids and essentially polyunsaturated fatty acids (PUFA). Almost no sequence variation, and thus no antigenic diversity, was detected in MSP between worms from different sub-populations or in the other Dictyocaulus species investigated. Estradiol level in plasma did not have any correlation with the PMNs migration in vitro.(ABSTRACT TRUNCATED AT 250 WORDS) All three peptides lyse with high anionic content bilayers, but show no activity at neutral pH and reach maximal activity at very high pH.

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Release 2.0 contains 765 full-length homeodomain-containing sequences, 29 experimentally derived structures and 116 homeobox loci implicated in human genetic disorders. An international research program is currently being developed that relies on the introduction of the bacterial endosymbiont Wolbachia pipientis into Aedes aegypti to control dengue transmission. The construction of four vectors for high-level expression in Escherichia coli of the phosphatidylinositol-specific phospholipase C from Bacillus cereus or Bacillus thuringiensis is described.

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The AIDS Attitudes Scale (AAS) developed by Froman, Owen, and Daisy in 1992 was used for this purpose. Data were analyzed 4 months before and 4 months after the implementation of the letter notification.

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Thus, we investigated the effects of the KD on neurogenesis after kainic acid (KA)-induced seizures in mice. A new approach for assessing non-cognitive attributes in medical school candidates was developed and implemented at the Hebrew University Medical School. The results demonstrate that (1) obvious change-points exist in all three hydrological series, (2) precipitation, temperature and irrigated area are all significant covariates of the annual runoff series, and (3) temperature increase plays the main role in leading to the reduction of the annual runoff series in the study basin, followed by the decrease of precipitation and the increase of irrigated area. Nonunion should be suspected if there is continuing pain after remobilization of the wrist in combination with a progressing deformity. We proposed that a single incision technique would offer equivalent outcomes with the potential for improved cosmesis and a reduced infection risk.

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The children from the experimental and the control group of the original study (Blaser et al., 2007) were retested by means of reading and writing tests at the end of the 3rd and 4th grades. Motion analyses were conducted with (1) a three-dimensional motion analysis system and (2) ground reaction force analysis using force platforms when subjects walked under three different insole conditions: no wedge, a low wedge with a 3-degree lateral angle, and a high wedge with a 6-degree lateral angle. We show here that endogenous alpha-catenin has little impact on the transcriptional activity of beta-catenin in developing mammalian organisms.

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(5E,7Z,10Z,13Z,16Z,19Z)-4-Hydroxy-5,7,10,13,16,19-docosahexaenoic acid (4-OHDHA) is a potential agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) and antidiabetic agent as has been previously reported. Simultaneous cesarean section and mitral valve replacement for infective endocarditis during pregnancy--a case report

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Zymography revealed an efficient blocking of enzyme activity of purified MMP-2 and MMP-9 and of MMP-containing cell supernatants (HT-1080), (A-673) using the PEGylated barbiturate 5. 31P magnetic resonance spectroscopy study of cerebral metabolism in developing dog brain and its relationship to neuronal function. Environmental, management, and genetic factors affecting semen production in Holstein bulls. Moreover, alcohol misuse, hyponatremia, renal insufficiency, and microbiota are actively explored.

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However, very few effective treatments are currently available to treat alcohol and drug addiction. Further validation and functional studies are needed to establish the potential regulatory role of these polymorphisms and their impact on susceptibility to carotid atherosclerosis. A 72-year-old female was found to have a large primary mesothelioma of the right flank musculature. Swabs were sent for microbiological studies of bacterial culture and antibiotic sensitivity.

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Known and influenceable risk factors were found to be less important than age and gender. In contrast with IBS, the degree of abnormality on breath test is greater in subjects with fibromyalgia and correlates with somatic pain. This study was designed to determine whether organisms from the seep site showed greater enzyme activity when compared to organisms from a non-seep reference site. Androgen insensitivity syndrome (testicular feminization): a model for understanding steroid hormone receptors.

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Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis. Surgical correction of foot deformities is generally indicated to relieve the disability. Improving derivatization efficiency of BMAA utilizing AccQ-Tag in a complex cyanobacterial matrix.

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Aromatase is the key enzyme in the biosynthesis of steroids, as it converts androgens to estrogens. In our study cohort with nonmetastatic renal cell carcinoma the preoperatively assessed AST/ALT ratio represented an independent prognostic factor. Female CRT recipients seem to achieve greater survival benefit than male recipients. A literature review showed only four cases of infantile simple cysts of the testis, only one of which was diagnosed preoperatively and treated by cyst excision. Autograft had greater advantages than irradiated allograft with respect to function and stability, whereas there were no significant differences between autograft and nonirradiated allograft.

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These effects of midazolam were interpreted as a contextually controlled deficit in the expression of conditioned fear that is similar to that associated with latent inhibition and extinction (M. Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis. Presurgically, children show a common profile of feeding and drooling impairment with negative effects on cosmetic appearance. In rice, genes are found at highest density in regions with frequent crossing-over.

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The findings also highlight the importance of cultural beliefs on the perceived stress levels among the Chinese population. Recently it has been observed that type 4 dipeptidyl peptidase (DPP-4) inhibitor linagliptin is effective for treating type 2 diabetes and albuminuria. Aging modifies the counterregulatory and symptomatic responses to hypoglycemia. As an example of the importance of humidity variable selection, we correlate numerous hourly humidity variables to daily respiratory syncytial virus isolates in Singapore from 1992 to 1994.

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In this study, we investigated the in vitro and in vivo immunomodulatory effects of haloperidol on DC-mediated immune responses. Cryptosporidiosis in Kuwaiti children: association of clinical characteristics with Cryptosporidium species and subtypes. Laparoscopic Hysterectomy for Endometrial Cancer: A Procedure 25 Years in the Making.

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An increase in the loading rate shows a higher interaction force between the heparin and thrombin, which can be directly linked to the kinetic dissociation rate constant (koff). Original research articles published in 2001 were analyzed by searching MEDLINE on the PubMed server to identify articles that may have represented a duplication of the original Radiology article. ISR has been defined from studies using Pseudomonas strains as the biocontrol agent.

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All persons underwent ultrasonographic examination (median nerve cross-sectional area at carpal tunnel entrance measurement--CSA) and median NCS studies (distal motor and sensory latency measurement--DML and DSL). A wide range of disease-causing mutations within ATP7A have been described, which lead to a diversity of phenotypes exhibited by Menkes patients. The immunoperoxidase technique is commonly used for the antigenic characterization of cells and tissues.

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Recent work has described the generation of a monoclonal antibody (MAb), designated DF3-P, that reacts with immature, underglycosylated precursors of DF3 antigen. However, large educational differences were still reflected in mortality risk differences within twin pairs, thus supporting some degree of independent effect of education. Images of an acrylic step wedge were acquired using the digital system in a mode that permitted direct control of effective detector latitude.

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Prognostic factors in vitrectomy for posterior segment intraocular foreign bodies. Bax/bcl-xl ratio, caspase 9 and caspase 3 mRNA expressions were significantly increased for 45 minutes of ODLG, but not for 30, 60, 75 and 90 minutes. Together, these data suggest that acquisition of conditioning proceeds by two stages of AMPAR trafficking.

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The tumor pool of free 5FU in those human tumors that trapped 5FU was determined to have a half-life of 0.4-2.1 hr, much longer than expected and significantly longer than the half-life of 5FU in blood (5-15 min), whereas the half-life of trapped 5FU in the VX2 tumors ranged from 1.05 to 1.22 hr. By using expression vectors, we demonstrate that the ets-1 gene transforms NIH3T3 cells and the ets-1 transfected cells form colonies in soft agar and induce tumors in nude mice. According to the international literature, the Authors maintain the absolute functional and anatomical individuality of this part of the large bowel, underlining the peculiarity of the sigmoidal junction neoplasms respect all the others colic sites regarding clinical manifestations, symptoms developing and biological behaviour. We first confirmed the binding of ANXA2 to IBV pseudoknot RNA by ultraviolet crosslinking and showed its binding to RNA pseudoknot with ANXA2 protein in vitro and in the cells.

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Severe hypercalcemia is the most common cause of death in patients with parathyroid carcinoma.The monoclonal antibody denosumab rapidly lowered severely elevated serum calcium levels due to parathyrotoxicosis.Denosumab was effective in the long-term treatment of hypercalcemia despite progression of parathyroid carcinoma. However, the degree of variation in burden among symptomatic COPD patients and the possible correlates of burden remain unclear. Does immunotherapy improve signs and symptoms of autonomic nervous system impairment in SS?

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The thermoseeds were produced from a nickel-copper alloy and electroplated with a gold-silver layer. Multicenter trial of cryotherapy for retinopathy of prematurity.

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An impairment of these mechanisms underlying UV-B-induced immunosuppression may be important in the pathogenesis of PLE. The study aimed to review systematically the diagnostic performance of the three imaging modalities. The genetic structures of other four indigenous species (Asia I, Asia II 1, Asia II 6, and China 1) with relatively wide distribution ranges in China were also discussed. Closely packed helices, in turn, facilitate interhelical hydrogen bonding of both weakly polar (Ser, Thr, Cys) and strongly polar (Asn, Gln, Glu, Asp, His, Arg, Lys) amino acid residues.

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Freeze-etching of Azotobacter vinelandii: examination of wall, exine, and vesicles. Primary pulmonary leiomyosarcoma is a rare malignant tumor of the lungs. Multiple kernel learning in protein-protein interaction extraction from biomedical literature.