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Epitomax (Topiramate)
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Topiramate

Epitomax is an oral drug that is used to prevent the seizures of epilepsy. It is an anti-epileptic or anti-seizure drug. It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Epitomax also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although Epitomax's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, Epitomax may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that Epitomax may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved Epitomax as a tablet in 1997. The sprinkle capsules were approved in October 1998.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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They had been treated with antihypertensive medication for less than 3 yr. FTIR spectroscopic imaging is a label-free, non-destructive and chemically specific technique that can be utilised to study a wide range of biomedical applications such as imaging of biopsy tissues, fixed cells and live cells, including cancer cells. Young children with a history of systemic reactions to imported fire ant (IFA) stings are at substantial risk of recurrent stings because of their maturational inability to practice appropriate avoidance techniques. Carcinoma of the nasal cavity and septum has historically been associated with a poor prognosis. We show that the viral EBNA1 protein, previously known to be required to maintain the EBV episomes, also causes the disruption of the cellular PML (promyelocytic leukemia) nuclear bodies (or ND10s).

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A multidimensional approach to medication selection in the treatment of children and adolescents with ADHD. So far, satisfactory results have been obtained with the modification of the incision line for open rhinoplasty. MSI and LOH may independently control the biological behaviors of digestive system cancers. A nitrate-permeable ion channel in the tonoplast of the moss Physcomitrella patens.

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Immune function is more compromised after closed bone fracture and hemorrhagic shock than hemorrhage alone. Diffusion of innovation: embedding simulation into nursing curricula. Moreover, miR-19a significantly attenuated mechanical allodynia and thermal hyperalgesia, and similar results were obtained after knockdown of SOCS1 expression.

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The present results, considered in the context of previous findings, suggest that more than one mechanism may be operative with respect to the effects of the plasmapheresis in increasing ECR1 levels defined by different epitopes on the molecule. Imaging findings on conventional radiography will be emphasized. Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?

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Patients were treated with subdermal mastectomy by means of external periareolar incision. In order to investigate the effects of the mechano-growth factor E (MGF-E) peptide, which is derived from the IGF-I alternative splicing isoform, on the regulation of the development of osteosarcoma, the expression of MGF was detected in osteosarcoma cell lines with different degrees of malignancy.

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Significant improvements are achieved for non-covalent interactions, with mean unsigned errors of 1.41 kcal/mol (OM2-D) and 1.31 kcal/mol (OM3-D) for the binding energy of the complexes in the JSCH-2005 data base. The effect of prolonged aspirin therapy on experimental balloon-catheter arterial wall injury. Induction of vacuolation in the mouse peritoneal macrophage by EDTA. Furthermore, we have investigated the proximal promoter regions from both pfmdr1 and pfcrt and identified a number of putative binding sites for nuclear receptors with sequence similarities to regions known to be activated by PB in mammals.

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These findings highlight the influence of these regions on integrative processing of food-related stimuli and increased ingestive behavior in obesity, or in the influence of hedonic ingestion on brain topological restructuring. In order to further elucidate the underlying natural variation in mouse primary somatosensory cortex, we measured the size of the posterior medial barrel subfield (PMBSF), associated with the representation of the large mystacial vibrissae, in an expanded sample set that included 42 BXD RI strains, two parental strains (C57BL/6J and DBA/2J), and one F1 strain (B6D2F1). In a series of experiments, crab-eating monkeys were fed cadmium-contaminated rice (1.33 micrograms Cd/g) or a diet containing 3 micrograms/g cadmium chloride for 6 years. The lateral pectoral flap is a new pedicled flap based on the superficial thoracic artery which arises from the subscapular artery and courses along the lateral border of pectoralis major.

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Isolated posterolateral corner (PLC) injuries are rarely seen with tibial plateau fractures and can be missed during the initial assessment. Cost-effectiveness of non-vitamin K antagonist oral anticoagulants for atrial fibrillation in Portugal.

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Asynchrony discrimination was measured for harmonic signals (experiment I) and for complexes in which the components were logarithmically spaced in frequency (experiment II). Tick-borne relapsing fevers of humans are caused by spirochetes that must adapt to both warm-blooded vertebrates and cold-blooded ticks. GAVIA represents the most comprehensive resource on the global distribution of alien species in any major taxon, allowing the spatial and temporal dynamics of alien bird distributions to be examined.

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A 7-week gestation pregnancy with placenta percreta was identified in the rudimentary uterine horn. Effect of diet on N,N-dimethyl-p-(m-tolylazo)aniline carcinogenesis in rats. Search of the protein database with the aflatoxin pathway polyketide synthase (PKS) revealed putative PKSs in the pathogenic fungi Coccidioides immitis and Coccidioides posadasii that could require partnerships with a pair of fatty acid synthase (FAS) subunits for the biosynthesis of fatty acid-polyketide hybrid metabolites.

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Microneurography: how the technique developed and its role in the investigation of the sympathetic nervous system. Changes in heat and radiation sensitivity during long duration, moderate hyperthermia in HeLa S3 cells. Occlusal adjustment was performed and topical sodium fluoride was applied to tooth surface. The application of FOB in patients with AECOPD during sequential weaning of invasive-noninvasive MV is effective in ICU. Coexistence of antiferromagnetic and spin cluster glass order in the magnetoelectric relaxor multiferroic PbFe 0.5 Nb 0.5 O3.

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In spite of abundant hepatic RNA expression of CLA-1, CLA-1 BAC transgenic mice had no significant effect on mouse HDL cholesterol. Twenty phases of sagittal sections were acquired within 6 sec, where the temporal resolution was 300 ms. New penicillins: properties, indications and basic elements of their therapeutic use The presence of scarce single pleomorphic cells in a bloody background should raise the diagnostic possibility of angiosarcoma. The hypothesis was that patient satisfaction is much greater with doctor led conventional follow-up as compared with nurse led out-patient follow-up.

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Significant changes may occur early during antibiotic treatment, and these changes may vary with the use of different antibiotics. Improvement of pesticide mineralization in on-farm biopurification systems by bioaugmentation with pesticide-primed soil.

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Standard amounts of dentin powder were tumbled with increasing concentrations of CHX (0-30 mM) for 30 min at 37 degrees C. Small molecules can be physicochemically targeted to mitochondria using the lipophilic alkyltriphenylphosphonium (TPP) group. The density of 12-14 Hz spindle frequency was higher in stage II when compared to stage delta, as in adults. Impact of an HMO-based intervention to increase mammography utilization.

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Characterization of casein kinase II, and of p98 as one of its effective phosphate acceptors in sea urchin eggs. Prophylactic use of ramosetron is more effective than granisetron for long-term prevention of nausea and vomiting after middle ear surgery. The findings should be interpreted with caution due to the small sample size in this study.

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The ICDAS-II system has demonstrated reproducibility and diagnostic accuracy for the detection of occlusal caries at varying stages of the disease process which are comparable to previously reported data using similar visual classification systems. Thus, in cases of outbreaks of coccidiosis, there is need to keep in mind such interaction between anticoccidials and mycotoxins. A 26-item anonymous survey was conducted of all of the active paramedics in a large urban EMS system where T-CPR had been practiced routinely for adults.

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at a dose of 5mg/kg/day with ethanol ad libitum for 6 weeks and then alone for 2 weeks during an abstinence period. Almost all of these nuclei were connected to the cerebellum through the mossy fiber system.

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The second pair of primers (LgHO) was also constructed, within the HO gene, composed of perfectly conserved sequences common for S. Malignant hepatic tumors: P-31 MR spectroscopy with one-dimensional chemical shift imaging. Later, two new species within the genus Gluconacetobacter, associated to coffee plants, were described in Mexico: G. Prognosis in these patients varies, depending on the extent of disease and left ventricular dysfunction. The results apparently reflect quantitative differences in enzymatic equipment and the metabolic pathways predominating in normal and neoplastic cells.

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Sporadic primary amyloidosis with exclusive peripheral and autonomic neuropathy IL-1R1-immunoreactive vessels were seen throughout the brain, but concentrated in the preoptic area, subfornical organ, supraoptic hypothalamus, and to a lesser extent in the paraventricular hypothalamus, cortex, nucleus of the solitary tract, and ventrolateral medulla.

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These results suggest that diffusion tensor magnetic resonance imaging-based tractography can be used to quantitatively evaluate nerve root function according to the area and morphology of fiber bundles of nerve roots. The Intensive Care Unit (ICU) is a data-rich environment where information technology (IT) may enhance patient care.

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The human visual system is proficient in perceiving three-dimensional shape from the shading patterns in a two-dimensional image. Characteristic paracentral scotomata due to focal photoreceptor atrophy can be detected using microperimetry. Morphological features in children with autism spectrum disorders: a matched case-control study. The two groups of cells also differed in their responsiveness to gustatory and olfactory stimuli: GS neurons were more likely to respond to tastes and odors than GIS cells.

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The discrete seasonal environments, wet season and dry season, are known to produce the two developmental forms and as a consequence impose alternating, symmetrical patterns of sexual selection, one season on male ornaments, the following season on female ornaments. The proposed configuration interaction schemes may be used to resolve space and spin symmetries in the calculation of electronic structures, exchange coupling constants, and other properties pertinent to polynuclear transition-metal complexes. This research challenges the assumptions of the perceptual load theory and sheds light on a neglected determinant of distractibility: the self-relevance of the performance situation in which attentional control is solicited. The combination of 3D-CISS and arterial flow-sensitive 3D-FISP, together with the evaluation criteria defined in this study, can be used for describing the finer anatomic features of the brain stem, and in particular for investigation of neurovascular contact of the IX/X cranial nerve root-entry zone.

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The binding of M5 also partially inhibits the proteolytic scission by trypsin of the bond between residues 77 and 78. Forty-nine patients with lung cancer (10 primary and 39 metastatic) underwent computed tomography-guided percutaneous RF ablation between June 2005 and October 2013.

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Many prokaryotic Ser/Thr kinases exhibit a wide variety of modular organization which indicates a degree of complexity and protein-protein interactions in the signaling pathways in these microbes. Bowel obstruction is a frequent complication after LRYGBP, particularly during the learn ing curve of the laparoscopic approach. Our results indicate that a limited neurogenic precursor subpopulation is present in cultures of avian neural crest cells and that the fate of this subpopulation can be influenced by environmental conditions arising when dispersal of neural crest cells is delayed. Polyphenols and phenolic acid are able to slow down or prevent oxidation processes and are therefore thought to have important effects in malting and brewing. After foot operations, Arnica D4 can be used instead of diclofenac to reduce wound irritation.

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Attitudes of Dublin accident and emergency department doctors and nurses towards the services offered by local general practitioners. Potential effects of the new Medicare Prospective Payment System on drug prescription in end-stage renal disease care. Colorectal cancer metastatic to the liver, when technically feasible, is resected with a moderate chance of cure. Evaluation of an immunochromatographic assay for rapid detection of Salmonella enterica serovars Typhimurium and Enteritidis.

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Benign prostatic hyperplasia (BPH) is characterized by abnormal epithelial and stromal proliferation causing urinary obstruction. Electron microscopy showed that the amyloid fibrils were in close contact with cytoplasmic expansions, or located in intracytoplasmic pockets of the infiltrating cells. To tackle this problem, first, a mollifier is used to smooth the cost function. In this article, the author reviews the recent important patents on GlyT-1 inhibitors for treatment of schizophrenia and other psychiatric diseases associated with the NMDA receptor hypofunction. Of the somata located in the FG, 44 were found to contribute their fibers to the nervus recurrens, 26 to the right frontal commissure, 28 to the left frontal commissure, and 6 to the nervus connectivus.

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Asthma and, more importantly, poorly controlled asthma are highly and disproportionately prevalent among school-aged urban minority youth, has a negative impact on academic achievement through its effects on cognition, school connectedness, and absenteeism, and effective practices are available for schools to address this problem. Therefore, we tested whether direct pharmacologic activation of AMPK could bypass defective mechanical signaling to restore nNOS activity in dystrophin-deficient cardiomyocytes. At the cellular level, 5-HT7 receptors increase the excitability of excitatory cells and appear to modulate both glutamatergic and GABAergic transmission in the hippocampus. Pairing of guanine to cytosine is affected by ruthenium complexation, with individual hydrogen-bonding energies being altered but the overall pairing energy remaining almost constant. With this aim, the biochemical and antigenic characteristics of T.

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Cellulose Nanofibers from Softwood, Hardwood, and Tunicate: Preparation-Structure-Film Performance Interrelation. Determining the time of diabetes mellitus onset by the level of glycosylated keratin in hair

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Correlation of this finding with hypocretin and leptin metabolism may further understanding of the pathogenesis of narcolepsy. When compared with other forms of aesthetic intracoronal restorations, ceramic inlays perform well. Optical microwell arrays for large-scale studies of single mitochondria metabolic responses. Values of transferrin in the follicular fluid were found to be highly correlated with those in serum, suggesting that the small contribution made by its localized synthesis in the granulosa cell may be important for some as yet unknown mechanism in follicle maturation. Body-fat depletion is a hallmark of cancer cachexia, a complex clinical syndrome associated with increased morbidity and mortality.

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The technique produces larger amounts of thin region as compared with ion milling and eliminates the problems associated with ion beam damage. A 75-year-old male, who had been taking tranilast for allergic dermatitis for two months, was admitted for severe bladder stimulating symptoms which was unresponsive to antibiotic therapies. Simultaneous and interleaved acquisition of NMR signals from different nuclei with a clinical MRI scanner. In an 18-year-old male with Eisenmenger syndrome cyanosis and erythrocytosis were increasing. Effect of Age and Sex on the QTc Interval in Children and Adolescents With Type 1 and 2 Long-QT Syndrome.

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The fabrication of arbitrary shape structures via control of the position and scan speed of the electron beam is further demonstrated. Concomitant cranial and abdominal symptoms were present in 7 of the 12 patients, and cranial symptoms were absent in 5 patients who presented with abdominal complaints. Model for nerve visualization in preoperative image data based on intraoperatively gained EMG signals.

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Twenty-seven procedures were performed on 20 patients with epiphora secondary to acquired nasolacrimal duct obstruction. The fast-track pathway for early reduction was introduced on January 9, 2011. However, OCTA alone did not distinguish between active and inactive CNVs and should be integrated into an MMI approach.

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Downregulation of HLA class I expression by c-myc in human melanoma is independent of enhancer A. Baseline variables were analyzed as potential predictors of self-reported smoking abstinence at Month 6 and at Month 24. Mitochondrial swelling and restorable fragmentation stimulated by femtosecond laser. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Energy-Cascaded Upconversion in an Organic Dye-Sensitized Core/Shell Fluoride Nanocrystal.

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Conversation focused aphasia therapy: investigating the adoption of strategies by people with agrammatism. Three top-performing methods (LSA, LLS and BPCA) are competitive with each other. The most conspicuous finding was transient hyperplasia of the SEL at 4-6 weeks of age which occurred in close proximity to an intact ependymal lining.

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The PL stimulation activates a neural network projecting to the amygdala via NMDA receptor-mediated glutamatergic neurotransmission. Induction of tyrosine hydroxylase gene expression by bacteria in the fat body of eri-silkworm, Samia cynthia ricini.

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Statistical analyses were performed using JMP 11.0 for the Macintosh. One hundred seven patients completed the SDQ, NDII, and SPADI on 4 occasions over 6 months, and underwent physical examination.

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Improved impact-parameter method for electronic excitation and dissociation of diatomic molecules by electron impact. For this purpose the HE histochemical stain and the avidin biotin peroxidase method was used. Detection of minimal residual disease of acute lymphocytic leukemia using TCR delta gene reconstitution We therefore conclude that abnormalities of liver enzymes are common in patients with HIV in this environment. Hybridization among sympatric species of Rhododendron (Ericaceae) in Turkey: morphological and molecular evidence.

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Antibodies to GBV-C in serum samples were detected by enzyme immunoassay based on a recombinant GBV-C E2 protein. Molecular and geographic data of New Guinea are consistent suggesting a series of speciation events starting approximately 3.7-4.3MYA leading to four extant Sericulus species. Previous work on the encapsulation of proteins and antigens in poly(lactic-co-glycolic acid) (PLGA) microspheres has led to the conclusion that microencapsulated antigens are frequently inactivated due to their interaction with the polymer.

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Cross-sectional study monitoring polymorbidity in hospitalized gerontopsychiatric patients. O-ribosyl-phosphate purine as a constant modified nucleotide norfloxacin dose for sbp located at position 64 in cytoplasmic initiator tRNAs(Met) of yeasts. During the BTK session (blood test stick with K-care), we observed a decrease in motor disorganization and extension movements and an increase in attention signs, both negative and positive. Phthalate esters in the environment: A critical review of their occurrence, biodegradation, and removal during wastewater treatment processes. This study involved 185 patients with pathologically confirmed PTC and clinically node-negative lateral neck.

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Clinicopathologic characteristics and surgical outcomes were compared between the two groups. Among these, pantoprazole 20 mg on demand is effective on the C2H2-type zinc finger proteins, with 176 members in Arabidopsis thaliana, constitute one of the largest families of transcriptional regulators in plants.

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These results further our understanding of the evolutionary mechanisms that drive virus variation, allowing orthopoxviruses to adapt to particular environmental niches. In contrast, the leukemia-associated fusion PML-RARalpha induced the degradation of HIPK2. Genomics-based early-phase clinical trials in oncology: recommendations from the task force on Methodology for the Development of Innovative Cancer Therapies. This patient was a 67-year-old male and prodec products australia pty ltd was admitted because of an abnormal lung shadow on chest X-ray.

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The events primarily responsible for mast cell proliferation in mastocytosis are largely unknown, but a derangement of the network involving c-kit receptor and its natural ligand (stem cell factor, which promotes mast cell growth and differentiation in man) is likely to have a primary role in onset of action of geodon weight this disease. We discovered that binding to the ganglioside GT1b, a toxin coreceptor, enables BoNT/B to sense low pH, undergo a significant change in secondary structure, and transform into a hydrophobic oligomeric membrane protein. Oxidative and nonoxidative glucose metabolism following graded doses of oral glucose in man.

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Recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. NMR assignment of TM1442, a putative anti-sigma factor antagonist from Thermotoga maritima. Bipolar ablation of the interventricular septum is more efficient at creating acitop acyclovir uses a transmural line than sequential unipolar ablation. An Experience of an Individual With a Chronic Wound in an Open Abdomen: A Grounded Theory.

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