Bespar is a novel anxiolytic agent unrelated to the benzodiazepines in structure or pharmacologic properties. Extensive clinical studies have shown Bespar to be effective in the treatment of anxiety, with efficacy comparable to diazepam or clorazepate. Bespar exhibits a unique pharmacologic profile in that it alleviates anxiety without causing sedation or functional impairment and does not promote abuse or physical dependence. Furthermore, pre-clinical studies have shown that Bespar does not possess anti-convulsant or muscle relaxant properties and does not interact significantly with central nervous system depressants. Biochemical and electrophysiologic studies indicate that Bespar alters monoaminergic and GABAergic systems in a manner different from that of the benzodiazepines. The uniform depressant action of the benzodiazepines upon serotonergic, noradrenergic, and dopaminergic cell firing may result from their facilitatory effect on gamma-aminobutyric acid and its known inhibitory influence in these monoaminergic areas. Unlike the benzodiazepines, Bespar exerts a differential influence upon monoaminergic neuronal activity, suppressing serotonergic activity while enhancing dopaminergic and noradrenergic cell firing. The mechanism of action of Bespar challenges the notion that only one neurotransmitter mediates anxiety. The interaction with multiple neurotransmitters at multiple brain sites suggests that Bespar may alter diverse activities within a “neural matrix of anxiety.” In contrast to the benzodiazepines, Bespar orchestrates activity within this neural matrix to achieve effective treatment of anxiety while preserving arousal and attentional processes.
Other names for this medication:
Buspirone,
Buspar,
Ansial,
Ansitec,
Ansiten,
Anxinil,
Anxiron,
Bespar,
Busansil,
Busirone,
Buspin,
Buspiron,
Buspirona,
Ledion,
Narol,
Neurosine,
Paxon,
Sorbon,
Spamilan,
Spitomin,
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